et al.
EARM-06 is a mathematical representation of apoptosis developed by B. Igus et al. in 2006. It consists of a system of 19 ordinary differential equations describing the dynamics of various signaling molecules involved in extrinsic, intrinsic and mitochondrial apoptotic pathways. It contains components of both the death receptor and mitochondrial pathways, as well as common downstream events such as caspase activation. In addition it includes positive and negative feedback loops which increase its accuracy in predicting the progression of apoptosis. Other components included are DNA fragmentation, cytochrome c release, as well as protein, mRNA and other molecule concentrations. After being calibrated with experimental data, EARM-06 can be used to analyze the effect of gene knockouts, alternatively spliced isoforms and other drug treatments to gain insight into the molecular and biochemical mechanisms behind apoptosis.